2 edition of Simulation and analysis of synaptic transmission in hippocampal dentate gyrus granule cells. found in the catalog.
Simulation and analysis of synaptic transmission in hippocampal dentate gyrus granule cells.
Stephan Fong-Jau Jou
Thesis (M.Sc.) -- University of Toronto, 1995.
|Series||Canadian theses = -- Thèses canadiennes|
|The Physical Object|
|Pagination||3 microfiches : negative. --|
Dentate granule cells are situated to regulate the flow of information into the hippocampus, a structure required for normal learning and memory. Correspondingly, impaired granule cell function leads to memory deficits, and, interestingly, altered granule cell connectivity may contribute to the hyperexcitability of limbic epilepsy. which the dentate gyrus innervates hippocampal area CA3, have yielded little evidence of an extralamellar or even overtly topographic organization (Claiborne et al., ). The hippocampal mossy ﬁber system comprises the den-tate gyrus granule neurons, their axons (the mossy ﬁbers *Correspondence to: Nicholas B. Hastings, Department of Cited by: Abstract. Developmental cuprizone (CPZ) exposure impairs rat hippocampal neurogenesis. Here, we captured the developmental neurotoxicity profile of CPZ using a region-specific expression microarray analysis in the hippocampal dentate gyrus, corpus callosum, cerebral cortex and cerebellar vermis of rat offspring exposed to 0, , or % CPZ in the maternal .
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Simulation and Analysis of Synaptic Transmission in Hippocampal Dentate Gyrus Granule CellsDepartment of Physiology and Institute of Biomedical Engineering, University of Toronto Using measurements from actual cells, a stochastic algorithm was developed and used to generate random rat dentate gyrus (DG) granule cell shapes which as a family look like.
In this Review, Thomas Hainmueller and Marlene Bartos examine the cells and circuits of the dentate gyrus, and discuss the evidence indicating that this brain region has multiple mnemonic by: 1. Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers.
Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell activity via feedback and feedforward by: Mody, I. and Heinemann, U., NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling, Nature (London) ( 7 Cited by: on the Soma of Pyramidal and Granule Cells 23 Gray Type I Synapses are Excitatory and are Located on Dendritic Spines 24 Long-lasting Alterations of Synaptic Efficiency After Physiological Stimulation 24 Hippocampal Systems: Exhibiting Several Types of Oscillatory Behavior 25 Studies of Epileptiform Behavior Sparse firing granule cells (GCs) in the dentate gyrus (DG) have been proposed to undertake this computation, but little is known about which of their properties influence pattern separation.
Dendritic atrophy has been reported in diseases associated with pattern separation deficits, suggesting a possible role for dendrites in this by: In turn, granule cells project their axons to the p yramidal cells in the CA3 area of the hippocampus, thus relaying the spatial and associa- tional.
Effect of GABA B receptors on synaptic interactions in dentate gyrus granule neurons of the rat. Jou S. () Simulation and analysis of synaptic transmission in hippocampal dentate gyrus granule cells. Thesis, University of by: Hippocampal GABAergic cells are highly heterogeneous, but the functional significance of this diversity is not Simulation and analysis of synaptic transmission in hippocampal dentate gyrus granule cells.
book understood. By using paired recordings of synaptically connected interneurons in slice preparations of the rat and mouse dentate gyrus (DG), we show that morphologically identified interneurons form complex neuronal networks. Synaptic Cited by: Pan E and Stringer JL, Burst characteristics of dentate gyrus granule cells: Evidence for endogenous and non-synaptic properties, J.
Neurophysiol. 75 Cited by: 4. (A) Low-magnification photomicrograph of a coronal brain section from an APP/PS1 mouse immunostained with anti-β-amyloid peptide (Aβ) and counterstained with toluidine blue.
Arrow indicates some Aβ plaques located in the molecular layer (ML) of the dentate gyrus (DG). (B) Toluidine blue-stained semithin section showing the DG and Aβ Cited by: The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories.
Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory by: Exercise improves cognition in humans and animals. Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain area important for learning and memory.
It is unclear how running modifies the circuitry of new dentate gyrus neurons to support their role in memory by: Grid cells in the rat medial entorhinal cortex fire (periodically) over the entire environment.
These cells provide input to hippocampal granule cells whose output is characterized by one or more small place fields. We sought to understand how this input–output transformation occurs.
Available information allows simulation of this process with no freely Cited by: The present study investigated the effect of morphine on synaptic transmission and long-term potentiation (LTP) in the dentate gyrus using rat hippocampal slice preparations.
Using a cross-disciplinary approach, we demonstrate that dopaminergic input in the dentate gyrus, a hippocampal subregion critical for the formation of high-resolution memories, impairs subsequent learning by suppressing cortical inputs and ensemble neuronal activity in this by: Abstract.
Structural rearrangement of the dentate gyrus has been described as the underlying cause of many types of epilepsies, particularly temporal lobe epilepsy. It is said to occur when aberrant connections are established in the damaged hippocampus, as described in human epilepsy and experimental models.
The hippocampal dentate gyrus is an intriguing structure, being one of the few mammalian brain regions capable of neurogenesis in adulthood and exhibiting synaptic plasticity that is influenced by relative neuronal age (19, 20).
Learning-related stimulation paradigms implemented in the dentate gyrus have also revealed a low. Granule cells in the dentate gyrus are only sparsely active in vivo and survive hippocampal sclerosis (HS) during temporal lobe epilepsy better than neighboring cells.
This phenomenon could be related to intrinsic properties specifically adapted to counteract by: The cortico-hippocampal circuit is implicated in the formation, storage, and retrieval of spatial and episodic memories (Lisman, ).The dentate gyrus (DG), the first stage in the hippocampal circuitry, receives abundant excitatory projections from the entorhinal cortex via the perforant-path (PP) by: 5.
After more than 30 years of study, the dynamics of synaptic plasticity in neurons still remain somewhat a mystery. By conducting a series of simulations on a simulated version of the rat dentate gyrus granule cell using the Izhikevich spiking neuron model, we compare and contrast several potential synaptic plasticity rules'.
Mossy fiber sprouting (MFS) has been observed in several animal models of TLE. The recurrent synaptic transmission between granule cells is one of the supposed inductors of a recurrent excitation between these cells and therefore is responsible for the generation of spontaneous seizures with probable origin in the hippocampus [8, 9].Cited by: 3.
The name granule cell has been used for a number of different types of neuron whose only common feature is that they all have very small cell bodies. Granule cells are found within the granular layer of the cerebellum, the dentate gyrus of the hippocampus, the superficial layer of the dorsal cochlear nucleus, the olfactory bulb, and the cerebral cortex.
Cerebellar granule cells. Pernía-Andrade and Jonas characterize the synaptic mechanisms underlying network oscillations and temporal coding in the dorsal hippocampus in awake rats. Theta-gamma-modulated synaptic currents may provide a framework for sparse temporal coding of information in the dentate by: The trisynaptic circuit consists of excitatory cells (mostly stellate cells) in layer II of the entorhinal cortex, projecting to the granule cell layer of the dentate gyrus via the perforant path.
The dentate gyrus receives no direct inputs from other cortical : Posterior cerebral, Anterior choroidal. The dendritic spines of dentate granule cells are the sites where the predominant stream of information from cortex arrives in the hippocampus. The findings presented here provide evidence that synaptic plasticity can rapidly influence the information storage capacity of synapses in dentate gyrus by: After more than 30 years of study, the dynamics of synaptic plasticity in neurons still remain somewhat a mystery.
By conducting a series of simulations on a simulated version of the rat dentate gyrus granule cell usingthe Izhikevich spiking neuron model, we compare and contrast several potential synaptic plasticity rules' applicability to the same experiment.
Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch-clamp study. Physiol. ; PubMedCited by: The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes.
Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. Neurogenesis, the creation of new brain cells called neurons, occurs primarily before birth. However, a region of the brain called the dentate gyrus, which is involved in memory, continues to produce new neurons throughout life.
Recent studies suggest that adding neurons to the dentate gyrus helps the brain to distinguish between similar sights, sounds Cited by: The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life.
Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of catastrophic interference when adapting to new by: Dentate granule cells receive predominant input from the medial septum, entorhinal cortex, and hilus [for review, see Ref.
In this context, while most studies in this area have concentrated on mossy fiber sprouting, it is clear that synaptic changes from sources other than granule cells might also contribute to the development of Cited by: 3.
3. The perforant path: projections from the entorhinal cortex to the dentate gyrus. Extrinsic afferent systems to the dentate gyrus. The mossy fibers. Mossy fiber synaptic transmission: communicating from dentate gyrus to area CA3. Development of cell and fiber layers in the dentate gyrus.
Genetic regulation of dentate gyrus Book Edition: 1. Construction and analysis of a variance‐mean plot. A, 5 consecutive EPSCs recorded from a granule cell in the dentate gyrus exhibit trial‐to‐trial amplitude fluctuations that contain information about synaptic function.
Each EPSC was preceded by a small voltage step to measure R s, and to ensure that recording conditions remained stable. B, EPSC amplitude Cited by: Serotonergic fibers from the raphe nuclei project to the hippocampal formation, the activity of which is known to modulate the inhibitory interneurons in the dentate gyrus Cited by: 4.
Dentate granule cells play a critical role in the function of the entorhinal‐hippocampal circuitry in health and disease. Dentate granule cells are situated to regulate the flow of information into the hippocampus, a structure required for normal learning and memory.
Correspondingly, impaired granule cell function leads to memory deficits, and, interestingly, altered granule.
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy. The Journal of Comparative Neurology. ;(2)– doi/cne  Sanchez RM, Ribak CE, Shapiro LA.
Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of by: Metabotropic γ-aminobutyric acid (GABAB) receptors contribute to the control of network activity and information processing in hippocampal circuits by regulating neuronal excitability and synaptic transmission.
The dysfunction in the dentate gyrus (DG) has been implicated in Alzheimer´s disease (AD). Given the involvement of GABAB receptors in AD, to determine. Dentate Gyrus model including Granule cells with dendritic compartments (Chavlis et al ) Dentate gyrus network model (Santhakumar et al ) Dentate gyrus network model (Tejada et al ) Dentate gyrus network model pattern separation and granule cell scaling in epilepsy (Yim et al ) Parvalbumin-positive basket.
Berger, T.W. and Weisz, D.J. Single unit analysis of hippocampal pyramidal and granule cells during classical conditioning of the rabbit nictitating membrane response.
In I. Gormezano, W.F. Prokasy and R.F. Thompson (Eds.), Classical Conditioning III: Behavioral, Neurophysiological and Neurochemical Studies in the Rabbit. Synaptic Transmission Subject Areas on Research.Adult hippocampal neurogenesis is a process involving the continuous generation of newborn neurons in the hippocampus of adult animals.
Mounting evidence has suggested that hippocampal neurogenesis contributes to some forms of hippocampus-dependent learning and memory; however, the detailed mechanism concerning how this small number of newborn Cited by: The dentate gyrus (DG) is the gateway of the hippocampal memory system, receiving cortical input from all sensory modalities, for forming episodic and spatial memories (Scharfman, ).
Its granule cells (DGCs) constitute the most numerous hippocampal Cited by: